肝纤维化遗传易感性研究进展

作者：朱慧玲 1   刘守胜 2 3   徐月 1   廖宋龄 1   辛永宁 3 4 5

单位：1.大连医科大学 辽宁 大连 116044 2.青岛市市立医院 中心实验室 山东 青岛 266071 3.青岛市消化疾病重点实验室 山东 青岛 266071 4.青岛市市立医院本部消化内二科 山东 青岛 266011 5.青岛市市立医院 感染科 山东 青岛 266011

关键词：慢性肝脏疾病 肝纤维化 遗传易感性

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出版年,卷(期):页码：2018,10(4):33-37

摘要：

摘要：慢性肝脏疾病最终可能进展为肝纤维化甚至肝硬化。遗传因素在慢性肝脏疾病进展为肝纤维化 过程中发挥重要作用。为更好地了解遗传因素在肝纤维化发病机制中的作用，探求肝纤维化临床治疗 的新靶点，本文总结了近年来与肝纤维化发病相关的遗传易感基因的研究进展，对全基因组关联分析 发现的基因（PNPLA3、TM6SF2、MBOAT7、MERTK、PDGFA和IL28B）进行详细论述。

Abstract: Many chronic liver diseases would progress to liver fibrosis or even liver cirrhosis eventually. Genetic factors play an important role in the progression of chronic liver diseases to liver fibrosis. In order to identify the role of genetic factors in the pathogenesis of liver fibrosis and explore new clinical therapeutic targets, we summarized and sorted out the latest research on genetic susceptibility genes related to the pathogenesis of liver fibrosis in recent years, especially the genes discovered by genome-wide association analysis, including the patatin-like phospholipase domain containing 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), membrane bound O-acyltransferase domain containing 7 (MBOAT7), myeloid-epithelial-reproductive tyrosine kinase (MERTK), platelet-derived growth factor A (PDGFA) and interleukin 28B (IL28B).

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