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摘要:丙型肝炎病毒非结构蛋白5A反式激活蛋白9(hepatitis C virus nonstructural protein 5A tran-
activator 9,NS5ATP9)参与多条信号转导通路,其可调控肝纤维化、细胞周期、肿瘤、DNA损伤修
复、自噬、软骨形成和造血干祖细胞发育等生理过程。本文将对NS5ATP9基因的结构、功能以及与信
号转导通路的关系进行总结,为后期对其作用机制和其他功能的深入探究奠定基础。
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Abstract: Hepatitis C virus nonstructural protein 5A tran-activator 9 (NS5ATP9) is a new gene found in
recent years, which takes part in a number of signal transduction pathways and regulates physiological
processes such as liver fibrosis, cell cycle, tumor, DNA damage repair, autophagy, chondrogenesis and
hematopoietic stem cells development. This review summarized the structure, function and signal transduction
pathways of NS5ATP9 in order to facilitate its further exploration of the mechanism of action and other
functions later in life.
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