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摘要：
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摘要：肝性脑病是急性肝功能衰竭和肝硬化患者常见的并发症，表现为从轻微认知障碍到昏迷等一系
列神经症状。根据临床表现可分为轻微肝性脑病、明显肝性脑病和昏迷；依据基础肝病的类型，HE
分为A、B、C 3型。10%～50%接受门体静脉分流术的患者1年内可发生明显的B型肝性脑病。肝性脑
病是影响预后的不利因素，1年内病死率为54%～85%。肝性脑病的发病机制尚未明确，本文通过对
肝性脑病发病机制的阐述，以期对临床诊断及治疗提供帮助。
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Abstract: Hepatic encephalopathy (HE) is a common complication of acute liver failure and liver cirrhosis. HE
presents as a spectrum of neuropsychiatric symptoms ranging from subtle fluctuating cognitive impairment to
coma. HE can be divided into minimal HE (MHE), overt HE (OHE) and coma. According to the type of basic
liver diseases, HE is divided into A, B and C types. The 1-year incidence of patients with type B OHE who
underwent transjugular intrahepatic portosystemic shunt (TIPS) is estimated to be 10%～50%. HE is a very
poor prognostic factor with a 1-year mortality of 54%～85%. The pathogenesis of HE is not clear. This review
explains the pathogenesis of HE, which is helpful for clinical diagnosis and treatment.
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