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摘要：
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摘要：肝脏是人体内最大的代谢器官，参与脂类、糖类和蛋白质等物质的合成与分解代谢。硫化氢
（hydrogen sulfide，H 2 S）是一种气体信号分子，参与调控多种病理生理过程。内源性H 2 S主要由胱硫
醚β-合成酶（cystathionine β-synthase，CBS）、胱硫醚γ-裂解酶（cystathionine γ-lyase，CTH）和3-巯
基丙酮酸硫基转移酶（3-mercaptopyruvate sulfurtransferase，MST）催化合成，上述3种酶均存在于肝
细胞中，通过催化产生的H 2 S参与调控肝脏功能。近年来大量研究表明肝脏中H 2 S的代谢影响脂蛋白
合成，肝脏中H 2 S代谢紊乱与脂肪肝和肝硬化的发生发展密切相关。本文主要对H 2 S在肝脏脂代谢的
生物学功能进行综述。
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Abstract: Liver is the largest organ in the body and is involved in regulating the synthesis and catabolism of
lipids, sugars and proteins. Hydrogen sulfide (H 2 S) has been recognized as an important signaling molecule,
regulating many physiological and pathological processes. H 2 S is synthesized from cysteine by cystathionine
β-synthase (CBS), cystathionine γ-lyase (CTH), and 3-mercapto-pyruvate sulfurtransferase (MST). All of the
above enzymes are present in liver cells, and involved in regulating liver function through catalytic production
of H 2 S. Many studies have suggested the metabolism of H 2 S in liver affects the synthesis of lipoprotein.
The disorder of H 2 S metabolism is closely related to the occurrence and development of fatty liver and liver
cirrhosis. This review focused on the biological function of H 2 S in lipid metabolism of liver.
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