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摘要：
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摘要：目的 探讨瞬时弹性成像（transient elastography，TE）技术在非病毒性肝病肝纤维化无创诊
断中的应用价值。方法 收集2015年1月至2016年7月于首都医科大学附属北京地坛医院经肝组织活检
诊断为非病毒性肝病患者的临床及病理资料进行回顾性研究。肝组织活检纤维化程度F0～F1为无显
著肝纤维化，F2～F4为显著肝纤维化，分析LSM值与肝组织活检纤维化分期的相关性，绘制ROC曲
线，计算LSM值诊断显著肝纤维化的AUROC、敏感性和特异度等。结果 共纳入96例符合条件的患
者，其中无显著肝纤维化者58例（60.42%），显著肝纤维化者38例（39.58%）。LSM值与肝组织活
检纤维化分期间相关系数r = 0.500（P < 0.001）。LSM值诊断显著肝纤维化的AUROC为0.795（P ＜
0.05）；当Cut-off值为11.45 kPa时，敏感性为60.5%、特异度为89.7%，阳性预测值为79.3%，阴性预
测值为77.6%。结论 LSM值与非病毒性肝病患者肝纤维化分期间有较好的相关性；TE对于非病毒性肝
病引起的肝纤维化有较高的诊断价值，可用于评估肝纤维化程度，动态监测肝纤维化进展。
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Abstract: Objective To investigate the value of transient elastography (TE) on non-invasive diagnosis of
liver fibrosis in patients with non-viral liver diseases. Methods Clinical and pathological data of patients who
underwent liver biopsy and diagnosed as non-viral liver diseases in Beijing Ditan Hospital, Capital Medical
University from January 2005 to July 2016 were collected and analyzed, retrospectively. Fibrosis stage of
F0～F1 were defined as non-significant liver fibrosis while the stage of F2～F4 were defined as significant
liver fibrosis. The correlation between liver stiffness measurement (LSM) value and the degree of liver fibrosis
determined by histopathological was analyzed. The ROC curve was plotted, the AUROC, sensitivity and
specificity of diagnosis for significant liver fibrosis by LSM value were calculated. Results The clinical and
pathological data of 96 patients with non-viral liver diseases were collected, 58 cases (60.42%) were in the
stage of non-significant liver fibrosis, while 38 cases (39.58%) were in the stage of significant liver fibrosis. The
correlation coefficient between LSM value of patients with non-viral liver diseases and histopathological degree
of liver fibrosis was 0.500 (P ＜ 0.001). The AUROC of significant liver fibrosis diagnosed by LSM value was
0.795 (P ＜ 0.05). When the Cut-off value was 11.45 kPa, the sensitivity was 60.5%, the specificity was 89.7%,
the positive predictive value was 79.3%, and the negative predictive value was 77.6%. Conclusions There is a
good correlation between LSM value and the stage of liver fibrosis in patients with non-viral liver diseases. TE
technology has a good value in diagnosing significant liver fibrosis caused by non-viral liver diseases, which can
be used to assess the stage of liver fibrosis and dynamically monitor liver fibrosis progression.
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