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摘要：
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摘要：肝细胞癌（hepatocellular carcinoma，HCC）合并门静脉癌栓（portal vein tumor thrombus，
PVTT），尤其是Ⅳ型癌栓者难治疗、预后差。本文报道1例初诊确诊为HCC合并Ⅲ型PVTT患
者，经肝动脉化疗栓塞（transcatheter arterial chemoembolization，TACE）1次 + 射频消融治疗
（radiofrequency ablation，RFA）1次 + 索拉非尼（400 mg，每日2次）治疗1个月后进展为HCC合并Ⅳ
型癌栓，经乐伐替尼（12 mg，每日1次）治疗1个月达肿瘤降期，再次联合TACE治疗1次 + RFA治疗1
次，肿瘤评估完全缓解（complete remission，CR）。
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Abstract: Patients of hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT), especially
those with type Ⅳ PVTT were difficult to treat and the prognosis was poor. This paper reported a newly
diagnosed case of HCC with type Ⅲ PVTT, who was treated by transcatheter arterial chemoembolization
(TACE) one time + radiofrequency ablation (RFA) one time + sorafenib (400 mg, twice per day) for one
month, then the case progressed to type Ⅳ PVTT and received lenvatinib (12 mg, once per day) for one
month, and the stage of tumor descended. The patient received TACE (one time) + RFA (one time) again, and
the tumor assessment reached complete remission (CR).
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