|
摘要：
|
|
摘要 目的 比较生活干预和水飞蓟宾治疗对非酒精性脂肪性肝病（non-alcoholic fatty liver disease，
NAFLD）患者的治疗效果。方法 收集2017年9月至2018年6月于中国人民武装警察部队后勤学院附属医
院就诊的NAFLD患者。根据治疗方式不同分为生活干预组和生活干预+水飞蓟宾组，同组内再根据患
者入组时的体质量指数（body mass index，BMI）分为肥胖组和非肥胖组，比较两组患者治疗前后体质
量、BMI、腰围、臀围、肝功能生物化学指标、空腹血糖（fasting blood glucose，FBG）、胰岛素及血脂
等指标。结果 共纳入符合条件的NAFLD患者284例，其中生活干预组129例，生活干预+水飞蓟宾组155
例。入组时同组内肥胖组的体质量、腰围、腰臀比及糖尿病患病率显著高于非肥胖组（P ＜ 0.05），
生活干预+水飞蓟宾组患者的ALT和稳态胰岛素抵抗指数显著高于生活干预组（P ＜ 0.05）。治疗3个
月后，两组患者的ALT、AST、血糖、血脂及CAP值均较治疗前有所下降，生活干预+水飞蓟宾组患者
ALT、FBG及CAP值较生活干预组改善更显著，且体质量降低更多（P ＜ 0.05）。结论 经生活干预+水飞
蓟宾治疗的NAFLD患者较单纯生活干预组患者体质量降低及ALT和肝脂肪变改善更好。
|
|
Abstract Objective To compare the effects of life intervention and silybin on patients with non-alcoholic fatty liver
disease (NAFLD). Methods Patients with NAFLD in Affiliated Hospital of Logistics University of People’s Armed
Police were collected and divided into life intervention group and life intervention + Silybin group according to
different intervention methods. The patients in the same group were divided into obese NAFLD patients and non-
obese NAFLD patients according to their body mass index (BMI). The body mass, BMI, waist circumference,
hip circumference, biochemistry of liver, fasting blood glucose (FBG), fasting insulin and blood lipid level were
compared before and after treatment. Results A total of 284 patients with NAFLD were enrolled, 129 cases in life
intervention group and 155 cases in life intervention + Silybin group. The body mass, waist circumference, waist-
hip ratio and diabetes prevalence of obese NAFLD patients were significantly higher than those of thin NAFLD
patients in the same group (P ＜ 0.05). The levels of ALT and homeostasis model assessment for insulin resistance
indexes of patients in life intervention + Silybin group were significantly higher than those in life intervention group
(P ＜ 0.05). After 3 months of treatment, the ALT, AST, blood glucose, blood lipid level and CAP value of patients in
both groups improved. The ALT, CAP value and fasting blood glucose level of patients in life intervention + Silybin
group improved and the body weight decreased more significantly than those in life intervention group (P ＜ 0.05).
Conclusion The body mass of patients with NAFLD who underwent life intervention + Silybin treatment decreased
more and the liver function and steatosis improved better than those who undewent life intervention treatment.
|
|
基金项目：
|
|
|
|
作者简介：
|
|
|
|
参考文献：
|
|
|
|
服务与反馈：
|
|
【文章下载】【加入收藏】
|
|
|
|