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摘要：
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摘要：脂肪沉积及胆汁酸（bile acid，BA）和脂类代谢紊乱是非酒精性脂肪性肝病（non-alcoholic
fatty liver disease，NAFLD）发生发展过程中的标志性特征。法尼醇受体（farnesoid X receptor，
FXR）通过参与BA的合成、分泌和重吸收，在BA和胆固醇稳态中发挥作用，同时在调节脂质代谢和
抑制炎症方面也发挥重要作用。了解并调控FXR及上下游基因的表达有助于深入研究NAFLD的发病
机制，为预防和治疗NAFLD提供新思路，寻找新的潜在治疗靶点。
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Abstract: Fat accumulation and bile acid (BA) lipid metabolism disorders are hallmarks in the development
of non-alcoholic fatty liver disease (NAFLD). The farnesoid X receptor is closely related with synthesis,
secretion and reabsorption of BA, and plays a vital role in BA and cholesterol homeostasis, as well as in
regulating lipid metabolism and inhibiting inflammation. Revealing and regulating the expression of FXR and
upstream or downstream genes will delay the processing of NAFLD, and provide new ideas for the prevention
and treatment of NAFLD, and find new potential therapeutic targets.
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