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摘要：
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摘要：高迁移率蛋白B1（high-mobility group box-1 protein B1，HMGB1）是细胞死亡和存活的重要调
节因子。研究表明，HMGB1与多种肿瘤的诱发、生长、浸润和转移有关。肝细胞癌（hepatocellular
carcinoma，HCC）是最常见的肿瘤之一，其发生、发展与炎症密切相关。近年来，HMGB1在HCC中
的作用越来越受到关注。本文就HMGB1与炎症的关系及其在HCC发生、发展和治疗中作用的研究进
展进行综述。
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Abstract: High mobility protein B1 (HMGB1) is an important regulator of cell death and survival. Many
studies have shown that HMGB1 is closely related to the induction, growth, infiltration and metastasis of
various tumors. Hepatocellular carcinoma (HCC) is one of the most common tumors in the world. The
occurrence and development of liver cancer are closely related to inflammation. In recent years, the role of
HMGB1 in liver cancer has received increasing attention. In this paper, the recent research on the relationship
between HMGB1 and inflammation and its role in the occurrence, development and treatment of liver cancer
was reviewed.
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