|
摘要：
|
|
摘要：Hippo信号转导通路最早在果蝇体内被发现，具有调控细胞增殖和凋亡的作用。近年来研究表
明，该通路与肿瘤的发生发展关系密切。SAV1（Salvador homolog1）是Hippo信号转导通路的支架蛋
白和核心组件，可负向调控肿瘤细胞的增殖、分化，已成为研究热点。本文就SAV1的结构和功能及
其在肝细胞癌发生发展中的作用及机制进行综述。
|
|
Abstract: Hippo signaling transduction pathway, initially discovered in fruit flies, plays an important role in
regulating cell proliferation and apoptosis. Recent studies have revealed that tumor initiation and progression
could be tightly linked to altered Hippo signaling. SAV1 is believed to act as core components of the Hippo
pathway. SAV1 worked as a cancer suppressor in restrict cell number and promoting apoptosis in differentiating.
In recent years, studies have been intensively focused on effects of SAV1 in human tumorigenesis. This article
reviewed the structure and function of SAV1 and its role on the development of liver cancer.
|
|
基金项目：
|
|
|
|
作者简介：
|
|
|
|
参考文献：
|
|
|
|
服务与反馈：
|
|
【文章下载】【加入收藏】
|
|
|
|