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摘要：
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摘要：监测肝细胞的恶性转化对肝细胞癌的早期诊断和及时干预至关重要。肿瘤细胞主动或被动释
放核酸片段进入血液循环中，成为循环肿瘤DNA（circulating tumor DNA，ctDNA），其携带有与肿
瘤细胞一致的遗传信息。近几年，随着新一代基因检测技术的发展，基于“液体活检术”的ctDNA
检测以其独特的优势逐渐成为研究热点，被认为是新一代肿瘤分子标志物，现从循环细胞游离DNA
（circulating cell-free DNA，cfDNA）浓度、ctDNA基因突变和ctDNA的甲基化改变来阐述ctDNA检测
在肝细胞癌早期诊断中的作用。
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Abstract: Monitoring the malignant transformation of hepatocytes is very important for the early diagnosis
and timely intervention of hepatocellular carcinoma. Tumor cells actively or passively release nucleic acid
fragments into the blood circulation, becoming circulating tumor DNA (ctDNA), which carries genetic
information consistent with tumor cells. In recent years, with the development of next-generation gene
detection technology, ctDNA detection based on “liquid biopsy” has gradually become a research hotspot
with its unique advantages, considered as a new generation of tumor molecular marker. In this review, the role
of ctDNA detection in the early diagnosis of hepatocellular carcinoma is discussed from the concentration of
circulating cell free DNA (cfDNA), mutation of ctDNA gene and methylation of ctDNA.
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