|
摘要：
|
|
摘要：目的 探讨循环微小RNA 122（microRNA 122，miR-122）的表达水平对肝细胞癌
（hepatocellular carcinoma，HCC）的诊断价值。方法 以“miR-122、肝细胞癌、诊断”等为关键词
检索PubMed、OVID、Embase、万方数据和中国知网等数据库，收集2019年5月31日前公开发表的关
于循环miR-122用于HCC诊断的相关文献，按纳入标准筛选文献、提取资料并进行质量评价，采用
Metadisc 1.4和Stata 14.0软件对数据进行Meta分析，通过绘制森林图及综合受试者工作特征（summary
receiver operating characteristic，SROC）曲线等综合评价循环miR-122表达水平对HCC的诊断价
值。结果 共纳入14篇文献，累计病例1023例，对照1149例。循环miR-122诊断HCC的合并敏感性为
0.75，合并特异度为0.75，阳性似然比为3.11（95%CI：2.37～4.09），阴性似然比为0.28（95%CI：
0.22～0.37），诊断比值比为12.87（95%CI：7.86～21.08），SROC曲线下面积为0.857。研究存在较
高的异质性（P ＜ 0.001，I 2 = 79 %）。Deek’s漏斗图示不存在发表偏倚（Bias = 22.47，P = 0.14），
敏感性分析显示Meta分析结果并未过分依赖于某个研究，结论稳定。结论 循环miR-122表达水平对
HCC的诊断具有一定价值。
|
|
Abstract: Objective To investigate the diagnostic value of circulating microRNA-122 (miR-122) on
hepatocellular carcinoma (HCC). Methods The databases of PubMed, OVID, Embase, WanFang Data and
CNKI databases were searched by using miR-122, hepatocellular carcinoma, diagnosis and other key words.
Articles concerning circulating miR-122 on the diagnosis of HCC published before May 31st, 2019 were
collected. After screening for inclusion criteria, data extraction and quality assessment, Meta-analysis was
performed by MetaDisc 1.4 and Stata 14.0 software. The diagnostic value of circulating miR-122 on HCC
was comprehensively evaluated by drawing forest map and summary receiver operating characteristic (SROC)
curve. Results A total of 14 articles were included, including 1023 cases with HCC and 1149 cases of control.
The combined sensitivity and combined specificity of circulating miR-122 on the diagnosis of HCC were
both 0.75, positive likelihood ratio was 3.11 (95%CI: 2.37～4.09), negative likelihood ratio was 0.28 (95%CI:
0.22～0.37), and the diagnostic odds ratio was 12.87 (95%CI: 7.86～21.08). The area under SROC curve
was 0.857. There was a high heterogeneity in the study (P ＜ 0.001, I 2 = 79 %). Deek’s funnel plot showed no
publication bias (Bias = 22.47, P = 0.14), sensitivity analysis showed that the results of Meta-analysis were
not overly dependent on a certain study and the conclusion was reliable. Conclusions Circulating miR-122
has certain value on the diagnosis of HCC.
|
|
基金项目：
|
|
|
|
作者简介：
|
|
|
|
参考文献：
|
|
|
|
服务与反馈：
|
|
【文章下载】【加入收藏】
|
|
|
|