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摘要：
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摘要：非酒精性脂肪性肝病（non-alcoholic fatty liver disease，NAFLD）是最常见的慢性肝病之一，
其发病机制尚未完全明确。近期研究表明肠道菌群的改变参与了NAFLD的发生。在生理状态下，肠
道菌群与内外环境保持动态均衡，各种原因导致的肠道菌群失衡均可影响宿主的代谢、能量吸收及肠
道内分泌功能，与肥胖、高血压和血脂代谢异常等NAFLD的高危因素及肝纤维化、肝硬化等密切相
关，且在诱发机体代谢紊乱及胰岛素抵抗中具有重要作用。本文对近年来肠道菌群改变与NAFLD发
生发展的研究进展进行综述，以期为NAFLD的治疗提供新思路。
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Abstract: Non-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver
diseases and the pathogenesis has not been fully elucidated. Recent studies showed that changes in the
intestinal flora group contribute to the occurrence of NAFLD. Under normal physiology, intestinal flora
maintains a dynamic ecological balance to the internal and external environment. The imbalance of intestinal
flora caused by various factors can affect the metabolism, energy absorption and intestinal endocrine function
of the host, and it is closely related to the high risk factors of NAFLD, such as obesity, hypertension, lipid
metabolism, liver fibrosis and cirrhosis. The imbalance of intestinal flora plays an important role in inducing
metabolic disorders and insulin resistance. The development of intestinal flora changes and NAFLD in recent
years were reviewed in order to provide new ideas for the treatment of NAFLD.
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