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摘要：
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摘要：血小板减少是晚期肝病患者的常见并发症，是慢性肝病预后不良的独立预测因
子。血小板减少可能会影响既定治疗方案的实施，严重者会增加出血风险。因此，了
解慢性肝病血小板减少的机制并早期干预是必要的。慢性肝病血小板减少在过去被认
为是脾功能亢进的结果。近年来，随着血小板生成素机制及血小板生成素受体激动剂
的发现，研究人员对慢性肝病血小板减少有了新的理解。本文现对慢性肝病血小板减
少的原因进行综述。
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Abstract: Thrombocytopenia is a common complication of advanced liver diseases
and an independent predictor of poor prognosis of chronic liver diseases. Sometimes,
thrombocytopenia can affect the implement of the established treatment, which will
increase the risk of bleeding in severe cases. Therefore, understanding the mechanism of
thrombocytopenia in chronic liver diseases and early intervention are necessary. In the past,
thrombocytopenia in chronic liver diseases was considered as the results of hypersplenism.
With the discovery of the mechanism of thrombocytopenia and its receptor agonist in recent
years, researchers have a new understanding of thrombocytopenia in chronic liver diseases.
This paper summarized the causes of thrombocytopenia in chronic liver diseases.
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