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摘要：
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摘要：酒精性肝病是危害我国人民健康的主要肝脏疾病之一。我国酒精性肝病发病率
呈上升趋势。酒精性肝病的病因是过量饮酒，但其发病机制涉及乙醇代谢、氧应激损
伤、免疫损伤及肠道微生态紊乱。目前，酒精性肝病，特别是酒精性肝炎的发病机制
尚未完全阐明。酒精性肝病患者由于首诊时间较晚、戒酒困难及合并多系统损害等因
素，整体预后不佳。目前针对酒精性肝病多学科诊疗体系尚不完善，针对酒精性肝病
患者有效治疗药物尚不足。亟需我们深入开展酒精性肝病相关基础与临床研究，规范
并优化酒精性肝病患者的诊疗以改善患者预后。
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Abstract: Alcoholic liver disease (ALD) is one of the major liver diseases endangering the
health of people. Prevalence of ALD is increasing in China. Excessive alcohol use is etiology
of ALD. However, alcohol metabolism, oxidative stress damage, immune damage and
dysbiosis are all involved in the cause of ALD. The pathogenesis of ALD, especially alcoholic
hepatitis, is still not clear. Due to the late diagnosis, difficult of abstinence, and multiple
organ dysfunction, the overall prognosis of patients with ALD is still poor. Currently, the
multidisciplinary treatment system is still improvable. Effective drug for ALD is still lacking.
Basic and clinical research of ALD is in urgent need. Effort should be paid on standardizing
and optimizing the management of ALD, as to improve the prognosis of these patients.
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