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摘要：
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摘要：慢性乙型肝炎（chronic hepatitis B，CHB）是我国重要的公共卫生问题。目前，
核苷（酸）类似物 [nucleos(t)ide analogs，NAs] 是抗病毒治疗的一线用药，其长期服
用的安全性问题也引起了临床医师的广泛关注。有研究表明，NAs抗病毒治疗可能影
响脂质代谢，不同药物对脂质代谢的影响不同，脂质代谢又与CHB的疾病进展密切相
关。因此谨慎评价NAs对脂质代谢的影响及其临床相关性具有重要意义。
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Abstract: Chronic hepatitis B (CHB) is an important public health problem in China. At present,
nucleos(t)ide analogs (NAs) are the first line drugs for antiviral treatment, the safety of long-term
use has also attracted wide attention from clinicians. Studies showed that NAs could affect lipid
metabolism, and the effects of different drugs on lipid metabolism may be different. Dyslipidemia
is closely related to the progress of CHB. Therefore, it is of great significance to carefully evaluate
the effects of NAs on lipid metabolism and its clinical correlation.
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