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摘要：
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摘要：乙型肝炎病毒（hepatitis B virus，HBV）感染常呈慢性化，其相关终末期肝病主
要包括肝硬化、肝衰竭和肝癌等。其中慢加急性肝衰竭（acute-on-chronic liver failure，
ACLF）是导致我国慢性HBV感染者预后不良、短期病死率激增的一组重要临床综合
征。目前许多研究表明HBV相关肝病会合并免疫紊乱，从而使患者易受各种病原体侵
袭，同时感染又会加剧肝功能衰竭，使疾病预后进一步恶化。本文旨在探究HBV相关
ACLF合并感染的机制、危险因素及可能的治疗措施。
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Abstract: Hepatitis B virus (HBV) infection is often chronic, which is related to end-stage liver diseases
including liver cirrhosis, liver failure, hepatocellular carcinoma and so on. As an important clinical
syndrome, acute-on-chronic liver failure (ACLF) leads to poor prognosis and sharp increases in shortterm mortality of patients with chronic HBV infection. Many studies have proved that HBV-related liver
diseases are associated with immune disorders, which makes patients vulnerable to various pathogens.
Meanwhile, infections can aggravate liver failure and make the prognosis even worse. This article aimed to
explore the mechanism, risk factors and possible treatment of HBV-related ACLF with infection.
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