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摘要：
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摘要：脂肪因子在单纯性脂肪肝（non-alcoholic simple fatty liver，NAFL）、非酒精
性脂肪性肝炎（non-alcoholic steatohepatitis，NASH）、肝纤维化、肝硬化乃至肝癌
的发生发展过程中发挥重要作用。对脂肪因子及其信号转导途径的研究有助于非酒精
性脂肪性肝病（non-alcoholic fatty liver disease，NAFLD）的诊断及治疗新靶点的挖
掘。本文通过对瘦素、脂联素、趋化素、抵抗素、Nrg4、SDF-1、EPDR1、IL6/IL27及
isthmin-1等脂肪因子的综述探讨NAFLD相关脂肪因子及其信号通路研究的新进展。
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Abstract: Adipokines play an important role in the development of non-alcoholic simple fatty
liver (NAFL), non-alcoholic steatohepatitis (NASH), liver fibrosis, liver cirrhosis and even
liver cancer. The studies in adipokines and their signal transduction pathways will contribute
to diagnosing and digging new therapeutic targets for non-alcoholic fatty liver disease
(NAFLD). This paper explored new progress in the study of adipokines associated with
NAFLD and their signal pathways through reviewing leptin, adiponectin, chemerin, resistin,
Nrg4, SDF-1, EPDR1, IL6/IL27, isthmin-1 and so on.
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