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摘要：
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摘要：乙型肝炎相关慢加急性肝衰竭（hepatitis B virus-related acute-on-chronic liver
failure，HBV-ACLF）是一种短期病死率极高的临床综合征，其发病机制尚不完全明
确，除肝移植外尚无有效的治疗措施。肝移植常受限于肝源不足、治疗费用高昂等因
素，因此内科综合治疗（包括人工肝支持系统）就成为提高患者短期生存率的重要手
段。本文将重点阐述HBV-ACLF的发病机制及内科综合治疗相关进展。
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Abstract: Hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) is a
complicated syndrome with extremely high short-term mortality. The pathogenesis of HBVACLF has not been fully elucidated, and there is no effective treatment except for liver
transplantation. Liver transplantation is limited by the shortage of donor livers and high costs
of the treatment. Thus, the comprehensive medical treatment (including artificial liver support
systems) emerged as an important intervention for improving short-term survival of patients
with HBV-ACLF. This paper focuses on the pathogenesis of HBV-ACLF and recent progress
of comprehensive medical treatment.
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