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摘要：
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摘要：肝性脑病（hepatic encephalopathy，HE）是由急性或慢性肝功能不全、门静脉
分流或两者兼有引起的神经精神异常综合征，其具体发病机制尚未明确，目前研究证
实，高氨血症、渗透和氧化/亚硝化应激、类淋巴回流、炎症细胞因子、锰沉积、低钠
血症、肠道菌群等因素，被认为在一定程度上引起星形胶质细胞的功能障碍及小胶质
细胞活化，进一步引发脑功能障碍，从而促使HE的发生与发展。本文对星形胶质细胞
功能障碍和小胶质细胞活化与肝性脑病发病机制的关系进行综述。
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Abstract: Hepatic encephalopathy (HE) is a neuropsychiatric syndrome caused by acute or
chronic hepatic insufficiency, portal vein shunting or both. Its specific pathogenesis has not
been explained clearly, and current studies have confirmed that hyperammonemia, osmotic
and oxidative/nitrosative stress, lymphoid system, inflammatory cytokines, manganese
deposition, hyponatremia, intestinal flora and other factors are believed to cause dysfunction
of astrocytes and microglia activation to a certain extent, further triggering brain dysfunction,
thereby promoting the occurrence and development of hepatic encephalopathy. In this article,
the relationship between astrocyte dysfunction and microglia activation and the pathogenesis
of hepatic encephalopathy was reviewed.
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