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Abstract: Ferroptosis is a form of programmed cell death which is different from apoptosis, the
main mechanism is the increase of bivalent iron or the imbalance of antioxidant system in vivo,
which produces a large number of lipid peroxides and finally leads to cell death. Ferroptosis is
involved in the occurrence of a variety of cancers and is considered to play an important role in the
pathogenesis of cancer. Hepatocellular carcinoma (HCC) is the most common malignant tumor in
China. In recent years, a large number of studies showed that ferroptosis played an important role
in the pathogenesis, treatment insensitivity and acquired drug resistance of HCC, which had been
widely concerned by many researchers. This paper summarized the main regulatory pathways and
key regulatory factors of ferroptosis in HCC, as well as its potential application in the treatment of
HCC, so as to provide new ideas for the accurate treatment of HCC.
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