内质网应激在代谢相关脂肪性肝病中的作用机制研究进展

作者：韦何锐1  肖凡2 3 4 5  魏红山1

单位：1. 首都医科大学附属北京地坛医院 消化科 北京 100015 2. 首都医科大学附属北京地坛医院传染病研究所 新发突发传染病研究北京市重点实验室 北京 100015 3. 北京市感染性疾病研究中心 北京 100015 4. 国家传染病医学中心 首都医科大学附属北京地坛医院 北京 100015 5. 传染病溯源预警与智能决策全国重点实验室 北京 100015

关键词：代谢相关脂肪性肝病 非酒精性脂肪性肝病 内质网应激 未折叠蛋白反应

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出版年,卷(期):页码：2024,16(1):13-17

摘要：

摘要：随着人类生活方式的改变，代谢相关脂肪性肝病（metabolic dysfunctionassociated fatty liver disease，MAFLD）的患病人群急剧扩张，目前MAFLD位于全世界 慢性肝病的首位。MAFLD可进一步发展为肝纤维化、肝硬化甚至肝细胞癌，严重威胁 人类健康。但目前其发病机制不明确，尚无批准的治疗手段。因此，越来越多的学者 研究MAFLD的发病机制，而内质网应激（endoplasmic reticulum stress，ERS）引发的 未折叠蛋白反应（unfolded protein response，UPR）对MAFLD的发展有着重要影响，其 参与胰岛素抵抗、脂质代谢、炎症和自噬等多个环节。本文将总结MAFLD疾病特征及 ERS在MAFLD的作用机制和研究现状，对发现MAFLD治疗靶点至关重要。

Abstract: As human’s lifestyle changing, the number of patients with metabolic dysfunctionassociated fatty liver disease (MAFLD) has expanded dramatically, MAFLD now ranks first in chronic liver disease worldwide. MAFLD may develop to liver fibrosis, liver cirrhosis and even hepatocellular carcinoma, which is a serious threat to human health. However, the pathogenesis of MAFLD is not clarified, and there is no approved treatment at present. Therefore, more and more scholars are devoted to the study of MAFLD. Importantly, unfolded protein response (UPR) induced by endoplasmic reticulum stress (ERS) is involved with insulin resistance (IR), lipid metabolism, inflammation, autophagy and so on, which has a great influence on the development of MAFLD. This article summarized the clinical characteristics of MAFLD and the mechanism and research status of ERS in MAFLD, which was crucial to discover therapeutic targets of MAFLD.

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