|
摘要：
|
|
摘要：乙型肝炎病毒感染相关慢加急性肝衰竭（hepatitis B virus-related acute-on-chronic
liver failure，HBV-ACLF）是在慢性乙型肝炎病毒感染导致的慢性肝病基础上，短期内
出现急性肝功能失代偿的临床综合征。HBV-ACLF具有病情进展迅速、治疗效果差、
死亡率高的特点。炎症和免疫应答是HBV-ACLF发生、发展及产生多器官、组织损伤
的重要原因。本文对超敏C反应蛋白、降钙素原、白细胞介素类、淋巴细胞亚群类、
趋化因子等炎症指标，以及超敏C反应蛋白/白蛋白比值、中性粒细胞/淋巴细胞比值、
血小板/白细胞比值等多因素指标在HBV-ACLF病情及预后判断中的应用进行综述，发
现动态观察炎症和免疫相关指标对HBV-ACLF预后判断、治疗方式选择等具有指导意
义，且多因素指标判断HBV-ACLF患者预后的灵敏度及特异度优于单因素指标。炎症
和免疫指标对HBV-ACLF患者预后判断具有指导意义。
|
|
Abstract: Hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) is a clinical
syndrome of acute liver dysfunction in the short term on the basis of chronic liver disease caused
by chronic hepatitis B virus infection. HBV-ACLF is characterized by rapid progression, poor
therapeutic effect and high mortality. Inflammation and immune response are important causes of
the occurrence, development and multiple organ and tissue damage of HBV-ACLF. This article
reviewed the application of inflammatory factors such as high-sensitivity C-reactive protein,
procalcitonin, interleukins, lymphocyte subsets, chemokines and other inflammatory indicators, as
well as high-sensitivity C-reactive protein / albumin ratio, neutrophil / lymphocyte ratio, platelet / white
blood cell ratio and other multi-factor indicators on the diagnosis and prognosis of HBV-ACLF. It
was found that the dynamic observation of inflammation and immune-related indicators had guiding
significance for the prognosis of HBV-ACLF and the choice of treatment methods, the sensitivity
and specificity of multi-factor indicators in the prognosis of HBV-ACLF patients were better than
those of single-factor indicators. Inflammation and immune indicators had guiding significance for
the prognosis of patients with HBV-ACLF.
|
|
基金项目：
|
|
|
|
作者简介：
|
|
|
|
参考文献：
|
|
|
|
服务与反馈：
|
|
【文章下载】【加入收藏】
|
|
|
|