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摘要：
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摘要：近年来，随着肥胖和代谢综合征的流行，脂肪性肝病的发病率呈上升趋势，已
取代慢性病毒性肝炎成为我国最常见的慢性肝脏疾病。脂肪性肝病与肝硬化、肝细胞
癌的发生密切相关，早期诊断并尽早干预有利于减轻疾病负担，控制疾病进展。肝穿
刺活检是诊断脂肪性肝病的“金标准”，但因有创、评价不一致和显著并发症等局限
性限制其广泛应用。目前临床迫切需要无创方法诊断脂肪性肝病，也需要无创标志物
筛查、监测患者病情变化和判断疗效。本文从脂肪性肝病的定义、疾病谱、有创诊
断、无创诊断几方面进行综述，以期为脂肪性肝病的诊疗工作提供帮助。
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Abstract: In recent years, with the prevalence of obesity and metabolic syndrome, the
incidence of fatty liver disease is on the rise, and it has been replaced chronic viral hepatitis
as the most common chronic liver disease in China. Fatty liver disease is closely related to
the occurrence of cirrhosis and hepatocellular carcinoma. Therefore, early diagnosis and
intervention are beneficial to reduce the burden of disease and control the progression of the
disease. Liver biopsy is the “gold standard” for the diagnosis of fatty liver disease, however,
its wide application is limited by invasiveness, inconsistent evaluation and significant
complications. At present, there is an urgent need for non-invasive methods to diagnose fatty
liver disease, as well as non-invasive marker screening, monitoring patients’ disease changes
and judging the curative effect. This paper reviewed the definition, disease spectrum, invasive
diagnosis and non-invasive diagnosis of fatty liver disease, in order to provide help for the
diagnosis and treatment of fatty liver disease.
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