初始抗戊型肝炎病毒免疫球蛋白M阴性的3例戊型肝炎病毒感染者临床特点分析

作者：邓浩辉1 2  梁淑珍1  刘惠媛2

单位：1. 佛山市顺德区第五人民医院（佛山市顺德区龙江医院） 感染科 广东 佛山 528318 2. 广州医科大学附属市八医院 重症肝病科 广东 广州 510000

关键词：肝炎病毒 戊型 免疫球蛋白M 临床分析

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出版年,卷(期):页码：2024,16(3):69-72

摘要：

摘要：戊型肝炎病毒（hepatitis E virus，HEV）是导致急性病毒性肝炎常见的病原体， 抗-HEV免疫球蛋白M（immunoglobulin M，IgM）是重要的诊断指标之一。本文报道 3例基因4型HEV感染者，患者在入院时初始抗-HEV IgM均为阴性，住院期间复查阳 转，抗-HEV IgM阳转时伴抗-HEV免疫球蛋白G（immunoglobulin G，IgG）阳转或水平 升高。3例HEV感染者的临床数据提示，对于肝功能异常原因未明且初始抗-HEV IgM 阴性的中老年和免疫功能缺陷的患者，建议重新检测抗-HEV IgM，以进一步确认或排 除HEV感染。

Abstract: Hepatitis E virus (HEV) is a common pathogen that causes acute viral hepatitis, anti-HEV immunoglobulin M (IgM) is one of the important diagnostic indicators. In this case report, three symptomatic HEV-infected patients who were initially anti-HEV IgM negative on admission and became positive during hospitalization were reported. When anti- HEV IgM is positive, it is accompanied by a positive conversion or elevated level of anti- HEV immunoglobulin G (IgG). The clinical features of the three symptomatic HEV-infected patients suggested that in clinical practice, older patients or patients with immunodeficiency status who had abnormal liver function with unknown causes and anti-HEV IgM negative on admission were recommended to undergo retesting of the serum anti-HEV IgM to further confirm or exclude HEV infection.

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