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摘要：
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摘要：代谢相关脂肪性肝病已是我国第一大慢性肝病，胰岛素抵抗与其发病密切相关。
胰岛素抵抗使脂肪组织功能紊乱，脂解释放大量游离脂肪酸入血。肝脏是参与脂肪酸代
谢的重要器官，过量的游离脂肪酸被肝脏摄取后，可通过多种途径造成肝脏脂质新生增
强、脂肪酸β氧化障碍和甘油三酯合成增加，最终使甘油三酯在肝细胞中以脂滴形式蓄
积而发生脂肪变性。循环中过量的游离脂肪酸可引起主要靶器官的胰岛素抵抗及肝脏炎
症反应。本文从过量游离脂肪酸对肝细胞内脂质蓄积、胰岛素抵抗、炎症反应的影响以
及西药和中药治疗代谢相关脂肪性肝病中脂肪酸代谢的研究进展进行综述。
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Abstract: Metabolic associated fatty liver disease has become the largest chronic liver disease in
China, and insulin resistance is closely related to its pathogenesis. Insulin resistance disrupts the
function of adipose tissue, and lipolysis releases a large number of free fatty acids into blood. Liver
is an important organ, which is involved in fatty acid metabolism. Excessive intake of free fatty
acids by liver can lead to enhanced liver lipogenesis, fatty acids β oxidative disorder and increased
triglycerides synthesis through various pathways, ultimately resulting in triglycerides accumulation
in hepatocytes in the form of lipid droplets and steatosis. Excessive circulation free fatty acids also
cause insulin resistance in main target organs and liver inflammation. This article reviewed the
effects of excessive free fatty acids on lipid accumulation, insulin resistance, and inflammatory
response in hepatocytes, as well as the research progress on fatty acid metabolism in the treatment
of metabolic associated fatty liver disease with Western medicine and traditional Chinese medicine.
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