Abstract: Objective To investigate the clinical effect of Liuweiwuling  tablets on chronic hepatic fibrosis. Methods Total of 128 cases with CHB were randomly divided into two groups. Both groups were treated on the basis of antiviral drugs.The treatment group (76 cases) were treated with Liuweiwuling tablets (1.5 g three times a day) besides the antiviral drugs. The course of the treatment was 24 weeks. The clinical symptoms, liver  function and  liver fibrosis indexes were observed. Results The clinical symptoms, liver function and liver fibrosis indexes of both groups were improved which were improved better in the treatment group than the control group (P ＜ 0.01). Conclusions Liuweiwuling tablets can protect hepatic cell, inhibit formation of inflammatory mediator as well as prevent and treat hepatic fibrosis.