Abstract: Objective To observe the clinical effect of Liuweiwuling tablets and adefovir dipivoxil  (ADV) on chronic hepatitis B (CHB) patients. Methods Total of 82 patients with CHB were randomly divided into two groups: treatment group were treated with Liuweiwuling tablets combined with ADV; control group were only treated with ADV. Both groups were treated for 24 weeks. The clinical symptoms, liver function and HBV DNA undetectable ratio were analyzed. Results The comprehensive clinical effect, live function recovery rate, negative conversion ratio of HBeAg and HBV DNA undetectable ratio were better than that in control group (P ＜ 0.05). Conclusions Liuweiwuling tablets combined with ADV has a positive curative effect on  improving clinical symptom, liver function recovery and hepatitis B virus  inhibition for CHB patients.