Abstract: Objective To explore the changes of platelet parameters: platelet (PLT), mean platelet volume (MPV) in patients with decompensated liver cirrhosis of hepatitis B with different HBV DNA levels and alcoholic liver cirrhosis. Methods Platelet parameters: PLT and MPV of 36 healthy people (control group),
38 cases of decompensated liver cirrhosis of hepatitis B with HBV DNA ＜ 105copies/ml, 36 cases of decompensated liver cirrhosis of hepatitis B with HBV DNA ＞ 105copies/ml and alcoholic liver cirrhosis were examined and analyzed by test. Results PLT of patients with decompensated liver cirrhosis of hepatitis B and alcoholic liver cirrhosis descended evidently compared with control group (P ＜ 0.05). PLT of patients with decompensated liver cirrhosis of hepatitis B with HBV DNA ＞ 105copies/ml descended evidently compared with decompensated liver cirrhosis of alcohol (P ＜ 0.05). PLT of patients with ecompensated liver cirrhosis of hepatitis B with different HBV DNA levels descended evidently (P ＜ 0.05). MPV of patients with decompensated liver cirrhosis of hepatitis B with HBV DNA ＞ 105copies/ml and alcoholic liver cirrhosis descended evidently compared with control group (P ＜ 0.05). MPV of patients with decompensated liver cirrhosis of hepatitis B with HBV DNA ＞ 105copies/ml descended evidently compared with decompensated liver cirrhosis of alcohol (P ＜ 0.05). MPV of patients with decompensated liver cirrhosis of hepatitis B with different HBV DNA levels descended evidently (P ＜ 0.05). Conclusions High HBV DNA level in patients with decompensated liver cirrhosis of hepatitis B may have effect on the decrease of PLT.