Objective To evaluate the efficacy and safety of adefovir dipivoxil tablets plus Anluohuaxian pill in  treatment of chronic hepatitis B. Methods Total of 45 patients with chronic hepatitis B were  randomly divided  into  treatment group  (30 cases) and control group  (15 cases),  treatment group  received adefovir dipivoxil  tablets plus Anluohuaxian pill  treatment, while  the control group only  received adefovir dipivoxil tablets therapy, both groups were treated for 24 weeks. Patients in two groups were detected for index of liver fibrosis,  liver function, serum detection of virological markers before and after  treatment. Results Adefovir dipivoxil  tablets plus Anluohuaxian pill  in  treatment of patients with chronic hepatitis B could  improve  the major symptoms and signs, liver function and fibrosis serous markers, which were better than patients treated with adefovir dipivoxil  tablets  (P ＜ 0.05), but  the difference of HBV DNA undetectable  rate and blood biochemical  index between  two groups were not significant  (P ＞ 0.05). Conclusions Adefovir dipivoxil tablets plus Anluohuaxian pill  in  treatment of chronic hepatitis B can  significantly  improve patients’ symptoms and signs, serous index of liver fibrosis and liver function and serous virological indicators, which were better  than adefovir dipivoxil  tablets alone  in serous  index of  liver  fibrosis and could significantly improve liver function and patients’ life quality, so it is worthy of clinical application.