中国肝脏病杂志(电子版)

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阿德福韦酯初治慢性乙型病毒性肝炎18例疗效观察

作者：孙一哲刘智慧郭晓华

关键词：阿德福韦酯乙型肝炎慢性肝硬化

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出版年,卷(期):页码：2010,2(3):18-20

摘要：

目的观察阿德福韦酯（ADV）对慢性乙型肝炎初治患者的临床疗效。方法将18例慢性乙型肝炎患者设为治疗组，在综合治疗基础上给予阿德福韦酯10 ㎎口服，每日1次；对照组选择同期住院患者11例，给予苦参素氯化钠注射液0.6 g静脉输注，每日1次，疗程为1个月。结果治疗组HBV DNA ＜ 10³拷贝/ml的比率、丙氨酸转氨酶（ALT）复常率和HBeAg血清学转换率分别为94.4%、88.9%和28.6%，对照组分别为9.1%、72.7%和14.3%，P ＜ 0.05。结论阿德福韦酯用于慢性乙型肝炎初治患者的效果较好。

Objective To observe the effect of adefovir dipivoxil (ADV) on chronic hepatitis B patients with initial treatment. Methods All of 18 cases with chronic hepatitis B were taken as the treantment group, who were treated by adefovir dipivoxil at 10 ㎎ orally once a day for a month after the regularly comprehensive therapy. The control group with 11 hospitalized patients at the same time were treated with matrine sodium chloride at 0.6 g intravenous injection once a day for a month. Results The rate of HBV DNA ＜ 10³ copies/ml,alanine aminotransferase normalization and HBeAg seroconversion were 94.4%, 88.9% and 28.6% in the experimental group, respectively, while in control group the corresponding rate were 9.1%, 72.7% and 14.3%,P ＜ 0.05. Conclusions The clinical effect of adefovir dipivoxil on chronic hepatitis B patients with initial treatment was significant.

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