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六味五灵片联合阿德福韦酯治疗慢性乙型肝炎临床研究

作者：周利军张旭力吕俊周容华

单位：湖北省武穴市第一人民医院武穴市 435400

关键词：肝炎乙型慢性六味五灵片阿德福韦酯

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出版年,卷(期):页码：2012,4(4):13-15

摘要：

摘要：目的观察六味五灵片联合阿德福韦酯（ADV）治疗慢性乙型肝炎（CHB）的临床疗效及安全性。方法采用随机、双盲、双模拟方法，选择CHB患者156例，按照1︰1比例随机分为治疗组与对照组各78例。治疗组给予六味五灵片联合ADV治疗，对照组单用ADV治疗。两组均给予常规保肝、对症、支持治疗，疗程均为48周，观察患者治疗前后临床症状、肝功能及HBV DNA变化。结果治疗后，两组患者临床症状、肝功能及HBV DNA指标均有所改善，且治疗组总有效率高于对照组（P ＜ 0.05）。结论六味五灵片联合ADV治疗慢性乙型肝炎临床疗效显著，且安全性良好。

Abstract: Objective To observe the clinical effect and security of Liuweiwuling tablets and adefovir dipivoxil (ADV) for chronic hepatitis B (CHB) patients. Methods Multicentre, randomized, double-blind and double simulation and control method was adopted in the study. Total of 156 patients with CHB was randomly divided into two groups: treatment group (n = 78) were treated with Liuweiwuling tablets combined with ADV; control group (n = 78) were treated only with ADV. Both groups were treated for 48 weeks. The clinical symptoms, liver function and HBV DNA undetectable ratio were analyzed. Results The clinical symptoms, liver function and HBV DNA undetectable ratio of treatment group were better than that in control group (P ＜ 0.05). Conclusions Liuweiwuling tablets combined with ADV has a positive curative effect on CHB patients.

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