Abstract: Objective To evaluate the efficacy and safety of silibinin capsules, compound liver-benepitino remedy and glucurolactone on patients with hepatic injury induced by antipsychotic drugs. Methods Total of 250 schizophrenia patients with abnormal liver function after taking antipsychotics were selected randomly from three psychiatric hospitals. Those patients were divided into three groups randomly and received the treatment of silibinin capsules, compound liver-benepitino remedy and glucurolactone, respectively. ALT, AST, TBil, GGT in three groups after 12 weeks treatment of three medicines were compared. Results The total effective rate of silibinin capsules, compound liver-benepitino remedy and glucurolactone were 86.16%, 90% and 85.5%, respectively. The differences on the level of ALT, GGT and TBil among three groups were compared not statistically significant at 4th weeks, 8th weeks and 12th week (P ＞ 0.05). AST level in the group receiving silibinin was lower than that of other groups at 4th week, and the differences were statistically significant (P ＜ 0.01). AST level in the group of receiving silibinin was also lower than that of other groups at 8th week, and the differences were statistically significant (P ＜ 0.05). But there was no significant different on AST, Cr, BUN and GLU levels respectively at 12th week among the three groups (P ＞ 0.05). Conclusions All three medicines could be used in antipsychotic-induced hepatic lesion effectively. Silibinin capsules reduces AST level faster than other groups at 4th week, and the degree of improvement is better than other groups.