Abstract: Objective To investigate the effects of growth hormone combined with enteral nutrition on liver function in rats with liver cirrhosis during perioperative period. Methods Total of 32 Wistar male rats with liver cirrhosis after partial hepatectomy were divided into four groups randomly: the control group, enteral nutrition (EN) group, growth hormone (GH) group, enteral nutrition combine with growth hormone (EN ＋ GH) group. Each group was comprised of eight rats. The liver function: albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST) were determined 5 days later. Results For EN ＋ GH group, the serum level of ALB is higher than that of the other three groups (all P ＜ 0.05), the serum levels of AST, AST were lower than those of the control group (all P ＜ 0.05). The serum levels of AST, ALT of EN group were lower than those of GH group (all P ＜ 0.05), but there were no difference between EN ＋ GH group and EN group (all P ＜ 0.05). Conclusions Growth hormone combined with enteral nutrition can improve the liver function of cirrhotic rat, and the hypoproteinemia effect is superior to each drug used alone, while the enzyme reducing effect had no significant difference compared with enteral nutrition used alone.