Abstract: Objective To study the clinical value of serum prealbumin (PA), total bile acid (TBA), coagulation indices and platelet’s parameters determination in assessment of liver cirrhosis patients. Methods Total of 140 patients with liver cirrhosis were divided into class Child-Pugh A group (38 cases ), Child-Pugh B group (60 cases), Child-Pugh C group (42 cases) according to the Child-Pugh score, 50 healthy people as control group, their serum PA, TBA, coagulation indices including prothrombin time (PT), activated partial thromboplatin time (APTT), thrombin time (TT) and fibrinogen (Fib), platelet’s parameters including platelet (PLT), mean platelet volume (MPV), platelet distribution width (PDW), platelet-large cell ratio (P-LCR) were detected and the differences between these groups were compared. Results Compared with healthy group, PA reduced, TBA elevated, PT, APTT and TT prolonged, Fib decreased, MPV, PDW and P-LCR increased, PLT decreased in the cirrhosis group (all P ＜ 0.01). With the increase of Child-Pugh grade in patients, their PA gradually decreased, TBA gradually increased (all P ＜ 0.01); coagulation indices PT, APTT, TT gradually prolonged, Fib gradually decreased (all P ＜ 0.01); platelet’s parameters MPV, PDW, P-LCR gradually increased, PLT gradually decreased (all P ＜ 0.01). Conclusions Serum prealbumin, total bile acid, coagulation indices, platelet parameters are closely related to Child-Pugh classification, combined detection of these indicators is of great significance in assessing the state and prognosis of patients with liver cirrhosis.