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血清十项肿瘤标志物联合检测对HBsAg阳性肝癌的诊断价值

作者：罗雪影 1 黄杰清2

单位：1. 广西来宾市中医医院广西来宾 546199 2. 广西凭祥市人民医院广西凭祥 532600

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出版年,卷(期):页码：2015,7(3):109-111

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摘要：目的探讨血清十项肿瘤标志物联合检测对乙型肝炎HBsAg阳性肝癌的诊断价值。方法统计分析2011年5月至2014年1月本院收治的292例HBsAg阳性肝癌患者的血清标本资料。结果肝癌组和非肝癌组患者的血清GP73和其余9种肿瘤标志物均有相关性（非肝癌组的9种肿瘤标志物的P = 0.000，肝癌组SF、CEA、CA125、CA15-3、ALP的P = 0.000；AFP的P = 0.007，CA19-9的P = 0.047；GGT的P =0.002，LAP的P = 0.028）；肝癌组患者的AFP、GGT、LAP相关系数均明显比非肝癌组小；肝癌组患者的GP73、AFP、LAP水平均明显比乙型肝炎肝硬化组、慢性乙型肝炎组、对照组高（P = 0.000）；GP73的ROC曲线下面积为0.792，比CA19-9、CA15-3、CA125、CEA、GGT、LAP、SF大（与CA19-9相比P = 0.002外，其余P = 0.000）；PRE的AUC均明显比其他单项指标高（P = 0.000）。结论血清十项肿瘤标志物联合检测对乙型肝炎HBsAg阳性肝癌具有较高的诊断价值。

Abstract: Objective To investigate the diagnostic value of combined detection of ten serum tumor markers on HBsAg positive patients with liver cancer. Methods The serum specimen data of 292 HBsAg positive patients with liver cancer (2011.05～2014.01) in our hospital were analyzed. Results The serum GP73 and other 9 kinds of tumor markers of the patients were correlated between liver cancer group and no liver cancer group (the P value of no liver cancer group was 0.000, the P values of liver cancer group in SF, CEA, CA125, CA15-3, and ALP were 0.000, and in AFP, CA19-9, GGT, and LAP were 0.007, 0.047, 0.002, 0.028, respectively); the correlation coefficient of AFP, GGT, LAP of patients in liver cancer group were significantly smaller than the non-liver cancer group. The level of GP73, AFP, LAP of liver cancer patients were significantly higher than hepatitis B cirrhosis group, chronic hepatitis B group and control group (P = 0.000); ROC area under the curve (AUC) of GP73 (0.792) was bigger than CA19-9, CA15-3, CA125, CEA, GGT, LAP and SF. AUC of PRE were obviously higher than other single indexes (P = 0.000). Conclusions The combined detection of ten serum tumor markers on HBsAg positive for hepatitis B liver cancer has high diagnostic value.

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