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血清同型半胱氨酸和降钙素原联合检测对于诊断肝硬化肝肾综合征的价值

作者：何均辉晏洁影雷平光文政伟

关键词：肝硬化肝肾综合征同型半胱氨酸降钙素原

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出版年,卷(期):页码：2015,7(4):47-49

摘要：

摘要：目的探讨血清同型半胱氨酸（Hcy）和降钙素原（PCT）联合检测在诊断肝硬化肝肾综合征
（hepatorenal syndrome，HRS）患者中的应用价值。方法选择2013年3月至2015年3月广东省深圳市
宝安区松岗人民医院收治的126例肝硬化患者，根据其是否并发HRS分为2组：非HRS组73例、HRS
组53例，对照组选取30例健康体检者。所有待测者均测定血清Hcy、PCT、CRP、WBC、N%；肝功
能指标ALB、ALT、TBil；肾功能指标Cys-C、24 h-Ccr，并进行相关的统计学分析。结果 HRS组和
非HRS组患者血清Hcy和PCT水平显著升高，且HRS组较非HRS组升高更为显著（P ＜ 0.05)。联合检
测Hcy和PCT可提高肝硬化HRS诊断的敏感性和准确性。结论 Hcy和PCT是肝硬化HRS的诊断指标之
一，对肝硬化及肝硬化HRS的诊断和治疗具有一定指导意义。

Abstract: Objective To investigate the value of serum homocysteine (Hcy) and calcitonin original (PCT) in
diagnosis of liver cirrhosis patients complicated with hepatorenal syndrome (HRS). Methods Total of 126
case of liver cirrhosis in the People's Hospital of Songgang from March 2013 to March 2015 were selected
and divided into non-HRS group (73 cases) and HRS group (53 cases), 30 cases of healthy people were
selected as the controls. Serum Hcy, PCT, CRP, WBC, N %, liver function indexes including ALB, ALT and
TBil, renal function indexes including Cys-C and 24 h-Ccr were detected and analyzed. Results The serum
Hcy and PCT levels of the two groups increased significantly, which increased more obviously in HRS
group than those of the non-HRS group (P ＜ 0.05). Combined detection of Hcy and PCT could improve the
sensitivity and accuracy of HRS in the diagnosis of cirrhosis. Conclusion Hcy and PCT are the diagnosis
indexes of the liver cirrhosis HRS, which have certain guiding significance for the diagnosis and treatment of
liver cirrhosis and HRS.

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