中国肝脏病杂志(电子版)

位置：首页 >> 期刊文章

乙型肝炎病毒血清学标志物定量结果表现模式分析

作者：孙瑾 1 赫程晨 2 杨倩 3 王珊珊 3 孙长俭 3

分类号：

出版年,卷(期):页码：2016,8(3):116-119

摘要：

摘要：目的探讨化学发光微粒子免疫分析技术（CMIA）检测乙型肝炎病毒（HBV）血清学标志物
定量结果的表现模式及临床意义。方法采用全自动化学发光微粒子免疫分析仪ARCHITECT-i2000SR
对21747例临床标本进行HBV血清学标志物定量测定，以数字序号1、2、3、4、5分别代表HBsAg、
HBsAb、HBeAg、HBeAb、HBcAb，并以检出阳性项目的序号为该模式的代码。结果本组病例共检
出18种表现模式，人群中HBV总感染率为5.05%，感染期以“145”和“135”为主，占87.71%；恢复
期以“2”、“245”、“45”和“5”为主，占92.64%；HBsAg（+）＜ 250 IU/ml和HBsAg（+）＞
250 IU/ml病例中，模式“135”比例分别为0.74%和23.55%，差异存在统计学意义（P ＜ 0.0001）。
结论 HBV血清学标志物定量结果的表现模式较为复杂，其与HBsAg定量结果均有助于判断乙型肝炎
患者的严重程度及疗效。

Abstract: Objective To investigate the performance mode and the clinical significance of chemiluminesent
micropartical immunoassay (CMIA) on detecting serological markers of HBV. Methods Total of 21747
serum samples were measured by automated ARCHITECT- i2000SR analyzer. The digital numbers 1, 2, 3, 4
and 5 represented HBsAg, HBsAb, HBeAg, HBeAb and HBcAb, and the number of positive items were used
to represent the detection mode. Results Total of 18 kinds of performance modes were found. The infection
rate was 5.05%. In infection stage, the “145” and “135” mode accounted for 87.71%; in recovery phase, the “2”,
“245”, “45” and “5” accounted for 92.64%. The rates of “135” mode in HBsAg (+)＜ 250 IU/ml and HBsAg
(+)＞ 250 IU/ml groups were 0.74% and 23.55%, respectively, the difference was statistically significant (P ＜
0.0001). Conclusions The modes of serological HBV markers are complicated, which can help to diagnose
the disease and to observe the curing efficacy in patients with hepatitis B.

基金项目：

作者简介：

参考文献：

服务与反馈：

【文章下载】【加入收藏】