Abstract: Objective To explore the predictive factors of early diagnosis of liver cirrhosis in chronic HBV
carriers (≥ 40 years old). Methods Total of 442 chronic HBV carriers (≥ 40 years old) underwent liver biopsy
in Hepatology Hospital of Jilin Province form August 2012 to August 2015, the fibrosis stage of 89 cases were
G4S4 (liver cirrhosis group) and 194 cases were below G2S2 (control group), these 283 cases were selected
as investigate objects. Liver function, peripheral blood cell counts, HBV DNA levels, HBsAg quantitative and
Fibroscan in both groups were analyzed and compared. Results The age, history of HBV infection, BMI and
proportion of drinkers in liver cirrhosis group were higher than those in control group, the difference were
statistically significant (P ＜ 0.05). The ALT, AST, ADA, ALP, GGT and PALB of patients in liver cirrhosis
group were (32.9 ± 7.4) U/L, (31.2 ± 10.3) U/L, (31.4 ± 10.1) U/L, (72.7 ± 31.6) U/L, (198.7 ± 32.8) U/L and
(112.9 ± 31.4) g/L, respectively; the corresponding indicators of patients in control group were (15.3 ± 3.6) U/L,
(29.8 ± 9.7) U/L, (10.7 ± 1.2) U/L, (22.6 ± 9.7) U/L, (102.8 ± 12.7) U/L and (311.7 ± 89.8) g/L, respectively,
the differences were statistically significant (P ＜ 0.05). PLT ＜ 110 × 10 9 /L and NEUT ＜ 2.0 × 10 9 /L were
independent risk factors for liver cirrhosis (OR = 29.33, 14.42, P ＜ 0.05). Fibroscan showed good coherence
with liver biopsy, and Kappa value was 0.75. HBV DNA levels and HBsAg had no correlation with liver
cirrhosis. Conclusion For chronic HBV carriers over 40 years, the age, history of hepatitis B, obesity, alcohol
intake, PLT ＜ 110 × 10 9 /L and NEUT ＜ 2.0 × 10 9 /L were risk factors for liver cirrhosis. Fibroscan showed
good coherence with liver cirrhosis.