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摘要：目的 探讨谷氨酰胺结合双歧杆菌四联活菌片在酒精性肝硬化患者治疗中的应用价值。方法 选
取2015年4月至2016年9月深圳市龙华区人民医院收治的酒精性肝硬化患者94例为研究对象，以随机
数字表法分为对照组和观察组，每组47例。对照组患者给予常规治疗，观察组在对照组基础上给予
谷氨酰胺结合双歧杆菌四联活菌片治疗，观察两组患者治疗前后肝功能（TBil、ALB和ALT）、肠黏
膜屏障功能（内毒素、D-乳糖和二胺氧化酶）变化及治疗后肠道症状发生情况。结果 治疗前两组患
者肝功能无显著差异（P ＞ 0.05），治疗后观察组患者的TBil和ALT水平显著低于对照组，ALB水平
显著高于对照组，差异有统计学意义（t值分别为5.813、4.273、6.044，P ＜ 0.001）。治疗前两组患
者肠黏膜屏障功能相关指标（内毒素、D-乳糖和二胺氧化酶）无显著差异（t = 0.934，P = 0.353；t =
0.125，P = 0.910；t = 0.081，P = 0.936），治疗后观察组患者各指标均显著低于对照组，差异有统计
学意义（t值分别为11.777、6.086、8.823，P ＜ 0.001）。观察组治疗后肠道症状发生率为8.51%，对
照组为23.40%，差异有统计学意义（χ 2 = 3.887，P = 0.049）。结论 谷氨酰胺结合双歧杆菌四联活菌
片可有效改善酒精性肝硬化患者的肠黏膜屏障功能，且能促进肝功能恢复，值得推广。
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Abstract: Objective To investigate the application value of glutamine combined with bifidobacterium quadruple
viable tablets on intestinal mucosal barrier function for patients with alcoholic cirrhosis. Methods Total of 94 cases
with alcoholic cirrhosis treated in People’s Hospital of Longhua District from April 2015 to September 2016 were
selected and divided into control group and observation group according to random digital table method, 47 cases
in each group. Patients in the control group were given routine treatment while patients in the observation group
were treated with glutamine combined with bifidobacterium quadruple viable tablets based on the routine treatment
in the control group. The changes of liver function (TBil, ALB, ALT), indexes of intestinal mucosal barrier function
(endotoxin, D-lactose acid, diamineoxidase) before and after treatment were observed. Intestinal symptoms after
treatment were also observed in both groups. Results There were no significant differences in liver function between
the two groups before treatment (P ＞ 0.05). After treatment, the levels of TBil and ALT in the observation group
were significantly lower than those in the control group, and the level of ALB was significantly higher than that
of the control group (t = 5.813, 4.273, 6.044; P ＜ 0.001). There were no significant differences in related indexes
of intestinal mucosal barrier function (endotoxin, D-lactose acid, diamineoxidase) between the two groups before
treatment (t = 0.934, P = 0.353; t = 0.125, P = 0.910; t = 0.081, P = 0.936). After treatment, the levels of endotoxin,
D-lactic acid and diamineoxidase in the observation group were significantly lower than those in the control group,
and the difference was statistically significant (t = 11.777, 6.086, 8.823; P ＜ 0.001). The incidence of intestinal
symptoms in the observation group was 8.51%, which was significantly lower than that in the control group (23.40%)
and the difference was statistically significant (χ 2 = 3.887, P = 0.049). Conclusions Glutamine combined with
bifidobacterium quadruple viable tablets can effectively improve the intestinal mucosal barrier function and promote
the recovery of liver function in patients with alcoholic cirrhosis, which is worthy of promoting.
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