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摘要：
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摘要：目的 探讨烯磷脂酰胆碱联合丁二磺酸腺苷蛋氨酸治疗急性病毒性瘀胆型肝炎患者的疗效。方
法 选取2016年4月至2017年8月于海口市第四人民医院治疗的急性病毒性淤胆型肝炎患者144例为研
究对象，采用随机数字表法将患者分为对照组和观察组，每组72例。对照组患者给予多烯磷脂酰胆
碱治疗，15 ml静脉滴注，1次/天，疗程4周；观察组患者在对照组基础上加用丁二磺酸腺苷蛋氨酸，
1.0 g静脉滴注，1次/天，疗程4周。比较两组患者治疗前后的生物化学指标，包括TBil、DBil、ALT、
AST、IL-17和TNF-α等。结果 治疗后观察组患者的TBil、DBil、ALT、AST、IL-17和TNF-α水平显著
低于对照组，差异有统计学意义（P ＜ 0.05）。观察组有效率为90.3%（65/72），显著高于对照组的
73.6%（53/72），差异有统计学意义（χ 2 = 2.524，P = 0.036）。结论 多烯磷脂酰胆碱联合丁二磺酸腺
苷蛋氨酸可降低急性病毒性瘀胆型肝炎患者IL-17和TNF-α表达，加速黄疸消退，保护患者肝功能。
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Abstract: Objective To investigate the effects of polyene phosphatidylcholine combined with ademetionine
1,4-butanedisulfonate on patients with acute viral cholestatic hepatitis. Methods Total of 144 patients
with acute viral cholestatic hepatitis in the NO.4 Hospital of Haikou from April 2016 to August 2017 were
enrolled. The patients were divided into control group and observation group according to random digital table
method, 72 cases in each group. Patients in control group were intravenously dripped with 15 ml polyene
phosphatidylcholine (one time per day) for 4 weeks, and patients in observation group were intravenously
dripped with 1 g ademetionine 1,4-butanedisulfonate (one time per day) for 4 weeks on the basis of the
control group. Blood biochemical indexes, including TBil, DBil, ALT, AST, IL-17 and TNF-α were compared
between the two groups before and after treatment. Results After treatment, the level of TBil, DBil, ALT,
AST, IL-17 and TNF-α of patients in observation group were significantly lower than those in control group,
with statistically significant difference (P ＜ 0.05). The effective rate in observation group was 90.3% (65/72),
which was significantly higher than that of control group [73.6% (53/72)], with statistically significant
difference (χ 2 = 2.524, P = 0.036). Conclusions Polyene phosphatidylcholine combined with ademetionine
1,4-butanedisulfonate can reduce the expression of IL-17 and TNF-α, accelerate the decline of jaundice and
protect the liver function of patients with acute viral choledocholic hepatitis.
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