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摘要：
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摘要：目的 分析海南黎族人群miRNA146a单核苷酸多态性（single nucleotide polymorphism，SNP）位
点与肝细胞癌（hepatocellular carcinoma，HCC）遗传易感性的关系。方法 选取2015年3月至2018年3
月于海南省人民医院接受治疗的45例肝脏良性疾病患者为对照组，选取2014年3月至2016年3月于本院
接受治疗的142例HCC患者为观察组，两组患者HBsAg均为阳性。取2组患者肝组织标本提取DNA后
行PCR扩增，查找包含miRNA146a外显子在内的SNP位点，探究miRNA146a与肿瘤易感性、患者术后
早期复发间的相关性。结果 HCC患者中miRNA146a rs2910164 C/C型54例，G/G型15例，C/G型73例，
Logistic分析表明HCC发生的危险因素为miRNA146a rs2910164 C/G型和C/C型，HCC早期复发的危险
因素为miRNA146a rs2910164 C/G型和肿瘤大小。结论 miRNA-146a rs2910164位点与海南黎族HCC患
者肿瘤遗传易感性有关，HCC患者术后早期复发的危险因素为rs2910164 C/G型和肿瘤大小。
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Abstract: Objective To analyze the miRNA146a single nucleotide polymorphism (SNP) and susceptibility of
patients with hepatocellular carcinoma of Li nationality in Hainan province. Methods A total of 45 cases with
benign liver disease in Hainan People’s Hospital from March 2015 to March 2018 were selected as control group
and 142 cases with hepatocellular carcinoma (HCC) who underwent hepatectomy in our hospital from March
2014 to March 2016 were selected as observation group. HBsAg of patients in both groups were positive. DNA
was extracted from liver tissue samples of two groups and then PCR was used to search for SNP sites including
miRNA146a exons to explore the correlation between miRNA146a and tumor susceptibility and early recurrence
after operation. Results There were 54 cases of miRNA146a rs2910164 C/C type, 15 cases of G/G type and 73
cases of C/G type in patients with HCC. Logistic analysis showed that the risk factors of occurrence of HCC were
miRNA146a rs2910164 C/G type and C/C type, and the risk factors of early recurrence of HCC were miRNA146a
rs2910164 C/G type and tumor size. Conclusions The miRNA-146a rs2910164 locus is associated with the genetic
susceptibility of HCC patients in Hainan Li nationality. The risk factors for early recurrence of patients with HCC
after operation are rs2910164 C/G type and tumor size.
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