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摘要：
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摘要：目的 探讨腹腔镜下结直肠癌切除术联合肝转移瘤射频消融术治疗结直肠癌肝
转移（colorectal cancer liver metastases，CRLM）患者的临床疗效。方法 选取2016年
5月至2017年3月于普宁市人民医院诊治的105例CRLM患者，按随机数字表法分为对
照组（50例）和观察组（55例），对照组行腹腔镜结直肠癌切除术联合肝转移灶切
除术，观察组行腹腔镜下结直肠癌切除术联合肝转移瘤射频消融术，采用独立样本t
检验比较两组患者相关手术指标（手术时间、术后肛门首次排气、住院时间等），采
用χ2检验比较术后并发症（吻合口狭窄、吻合口出血、切口感染等）、术后复发率及
生存率。结果 观察组患者手术时间 [（254.57 ± 33.41）min vs（290.52 ± 36.42）min；
t = 5.276，P ＜ 0.001]、术中出血量 [（187.16 ± 89.52）ml vs（383.63 ± 88.34）ml；t =
11.302，P ＜ 0.001]、术后肛门首次排气时间 [（2.48 ± 0.36）d vs（3.50 ± 0.25）d；t =
16.702，P ＜ 0.001]、住院时间 [（13.25 ± 4.60）d vs（18.73 ± 4.10）d；t = 6.419，P ＜
0.001]、治疗费用 [（37072 ± 505）元 vs（41059 ± 504）元；t = 40.442，P ＜ 0.001] 及术
后VAS评分 [（4.02 ± 0.26）分vs（7.25 ± 0.63）分；t = 34.906，P ＜ 0.001] 均显著低于
对照组。观察组和对照组患者观察组和对照组患者术后切口感染（1.82% vs 12.00%）、
吻合口狭窄（1.82% vs 4.00%）、吻合口出血（1.82% vs 4.00%）、输尿管损伤（1.82%
vs 4.00%）、吻合口瘘（0% vs 2.00%）、粘连性肠梗阻（1.82% vs 12.00%）、排尿困
难（0% vs 2.00%）等并发症发生率差异无统计学意义（P均＞ 0.05）。观察组和对照
组患者术后3年局部复发率分别为12.73%（7/55）、20.00%（10/50），差异无统计学
意义（χ2 = 1.021，P = 0.312）。观察组患者术后1年、2年和3年的生存率分别为90.91%
（50/55）、85.45%（47/55）、81.82%（45/55），对照组分别为90.00%（45/50）、
86.00%（43/50）、84.00%（42/50），差异均无统计学意义（χ2值分别为0.025、0.006、
0.088，P值分别为0.874、0.936、0.767）。观察组患者术后1年、2年和3年的无瘤生存
率分别为76.36%（42/55）、72.73%（40/55）、45.45%（25/55），对照组分别为76.00%
（38/50）、60.00%（30/50）、40.00%（20/50），差异均无统计学意义（χ2值分别为
0.002、0.062、0.318，P值分别为0.965、0.804、0.573）。结论 腹腔镜下结直肠癌切除
术联合肝转移瘤射频消融术可显著减少CRLM患者术中出血量，加快术后康复时间，减
少术后并发症，近期疗效和安全性良好。
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Abstract: Objective To investigate the clinical efficacy of laparoscopic colorectal cancer
resection combined with liver metastases radiofrequency ablation in treatment of patients
with colorectal cancer liver metastases (CRLM). Methods A total of 105 patients with CRLM
who were treated in Puning People’s Hospital from May 2016 to March 2017 were selected
and divided into control group (50 cases) and observation group (55 cases) according to the
random digital table method. Patients in control group were given laparoscopic colorectal cancer
resection combined with liver metastases resection, and patients in observation group were given
laparoscopic colorectal cancer resection combined with liver metastases radiofrequency ablation.
The operation parameters (operation time, first anal exhaust time after operation, hospital stay,
etc) of patients in both groups were compared by independent-sample t test, postoperation
complications (anastomotic stenosis, anastomotic bleeding, incision infection, etc.), recurrence
rate and survival rate of patients in both groups were compared by χ2 test. Results The operation
time [(254.57 ± 33.41) min vs (290.52 ± 36.42) min; t = 5.276, P ＜ 0.001], interoperative
bleeding volume [(187.16 ± 89.52) ml vs (383.63 ± 88.34) ml; t = 11.302, P ＜ 0.001], first
anal exhaust time after operation [(2.48 ± 0.36) d vs (3.50 ± 0.25) d; t = 16.702, P ＜ 0.001],
hospitalization time [(13.25 ± 4.60) d vs (18.73 ± 4.10) d; t = 6.419, P ＜ 0.001], treatment
cost [(37072 ± 505) yuan vs (41059.46 ± 504.73) yuan; t = 40.442, P ＜ 0.001] and VAS
score [(4.02 ± 0.26) points vs (7.25 ± 0.63) points; t = 34.906, P ＜ 0.001] of patients in
observation group were significantly lower than those of control group. The incidence
of complications including incisional wound infection (1.82% vs 12.00%), anastomotic
stenosis (1.82% vs 4.00%), anastomotic bleeding (1.82% vs 4.00%), ureteral injury (1.82%
vs 4.00%), anastomotic fistula (0% vs 2.00%), adhesive ileus (1.82% vs 12.00%) and dysuria
(0% vs 2.00%) of patients in observation group and control group were not statistically
significant (all P ＞ 0.05). The local recurrence rate within 3 years of patients in observation
and control group were 12.73% (7/55) and 20.00% (10/50), respectively, the difference was
not statistically significant (χ2 = 1.021, P = 0.312). The survival rates of 1 year, 2 years and 3 years
after surgery of patients in observation group were 90.91% (50/55), 85.45% (47/55) and
81.82% (45/55), respectively, which were 90.00% (45/50), 86.00% (43/50) and 84.00% (42/50)
in observation group, respectively, the differences were not statistically significant (χ2 = 0.025,
0.006, 0.088; P = 0.874, 0.936, 0.767). The tumor-free survival rates within 1 year, 2 years and
3 years after surgery of patients in observation group were 76.36% (42/55), 72.73% (40/55) and
45.45% (25/55), respectively, which were 76.00% (38/50), 60.00% (30/50) and 40.00% (20/50)
in observation group, respectively, the differences were not statistically significant (χ2 =
0.002, 0.062, 0.318; P = 0.965, 0.804, 0.573). Conclusions Laparoscopic colorectal cancer
resection combined with liver metastases radiofrequency ablation in treatment of patients with
CRLM can significantly reduce the amount of bleeding, speed up the recovery time, reduce
postoperative complications, with good short-term efficacy and safety.
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