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摘要：
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摘要：酒精性肝病（alcoholic liver disease，ALD）是长期过量饮酒导致的肝脏疾病，
也是世界范围内肝病患者死亡的主要原因之一。外泌体是细胞内多囊泡体与质膜融合
后分泌到细胞外的一种纳米级囊泡。在乙醇刺激下，外泌体大量形成并释放到细胞
外，其携带的核酸、蛋白质与脂质等物质在细胞间进行物质转运和信息传递从而调控
ALD的发生发展。近年来，外泌体在肝脏疾病中的作用及机制研究引起了广泛关注。
本文对外泌体在ALD中的功能进行综述。
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Abstract: Alcoholic liver disease (ALD) is caused by long-term excessive drinking and it is
one of the main causes of death in patients with liver diseases worldwide. Exosomes are nanosized vesicles that secreted outside the cells when multivesicular bodies in the cells are fused
with plasma membrane. Under the stimulation of ethanol, a large number of exosomes are
formed and released from the cells, and they carry materials such as nucleic acids, proteins
and lipids for material transport and information transmission between cells to regulate the
development of ALD. In recent years, researches on the role and mechanism of exosomes in
the field of liver diseases have attracted widespread attention. This article mainly reviewed the
functions of exosomes on ALD.
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