中国肝脏病杂志(电子版)

位置：首页 >> 期刊文章

腺苷蛋氨酸与前列地尔联合治疗肝衰竭高胆红素血症疗效观察

作者：朱金照张九妹王艳丽吕勇黎环刘晓燕

分类号：

出版年,卷(期):页码：2010,2(3):12-14

摘要：

目的观察腺苷蛋氨酸联合前列地尔对肝衰竭患者高胆红素血症的疗效。方法 110例肝衰竭伴高胆红素血症患者随机分成2组，其中治疗组60例，给予腺苷蛋氨酸每日2.0 g、前列地尔每日20 μg静脉输注；对照组50例，给予苦黄注射液每日50 ml、前列地尔每日20 μg静脉输注。两组均给予血浆置换等综合治疗，疗程为4周。观察两组总胆红素及其他主要肝功能指标的改善情况及总有效率。结果治疗后两组总胆红素及肝功能均较治疗前明显好转（P ＜ 0.05或P ＜ 0.01）；治疗组总胆红素、谷氨酰转肽酶下降较对照组更为显著（P ＜ 0.05），其他指标也优于对照组，但差异无统计学意义。治疗组总有效率高于对照组（P ＜ 0.05）。结论腺苷蛋氨酸联合前列地尔能更有效的降低肝衰竭患者总胆红素水平，提高治疗肝衰竭治疗的总有效率。

Objective To observe the effect of Sadenosyl methioninein (SAMe) combined with prostaglandin E1 in hyperbilirubinmia treatment of liver failure. Methods All of 110 liver failure cases with hyperbilirubinmia were randomly divided into treatment group and control group. The same basic therapy were given to two groups. SAMe and prostaglandin E1 were given to treatment group and control group were treated by Ku huang and prostaglandin E1 for 4 weeks. The indictors of liver functions such as serum alanine minotransferase (ALT), serum total bilirubin (TBil) and the total effective rate were analyzed. Results The indictors of liver functions were significantly improved after treatment than before (P ＜ 0.01 or ＜ 0.05). TBil and GGT in treatment group were much lower than those of control group (P ＜ 0.05). Total effective rate in treatment group was significantly higher than that in control group (P ＜ 0.05). Conclusions Sadenosyl methioninein (SAMe) combined with prostaglandin E1 in hyperbilirubinmia treatment of liver failure is effective and could significantly increase the total effective rate.

基金项目：

作者简介：

参考文献：

服务与反馈：

【文章下载】【加入收藏】